Zerene Stacker is a “focus stacking” program designed specifically for challenging macro subjects and discerning photographers.Zerene Stacker has several advantages over other commonly used stacking programs:

Highest quality output images, especially in difficult cases
Accurate and robust alignment and interpolation
Advanced stacking algorithms
Clean handling of hairs and bristles -- no halos or contour lines
Preserves low contrast detail and avoids "stacking mush" with deep stacks
Fast and flexible retouching makes it easy to combine the best features of multiple algorithms as well as original frames
Supports 8- and 16-bit input and output files
Designed to fully utilize modern multi-core processors and multi-processor computers

Zerene Stacker can handle most modern cameras. 15 megapixel images are routine. Most 32-bit machines can handle 21 megapixels. 64-bit systems have no practical limit except physical memory.