Lucifer drives Sam to the breaking point and Sam ends up in a mental hospital. Desperate to save his brother, Dean calls every hunter he knows for help. one of the hunters gives him the name of a healer who turns out to have a very familiar face.

When Nikita (Maggie Q) worked for Division, she targeted a man named Nicholas Brandt (guest star Rick Ravanello) and infiltrated his inner circle. She captured him and he�s been behind bars ever since. However, Percy (Xander Berkeley) springs Brant, and his first mission is to capture Nikita for payback. After he has her in his clutches, he tortures her, forcing Nikita to face a side of herself she thought she had long buried. Meanwhile, Percy continues to play mind games with Michael (Shane West), Alex (Lyndsy Fonseca) and Sean (Dillon Casey), pushing one of them to the brink of death.

Lincoln travels to the other side to join forces with Bolivia and his own alternate, as they search for a vigilante with a surprising connection to the shapeshifters.